气相色谱法检测不同基质化妆品中角鲨烷的方法
Determination of Squalane in Cosmetics with Different Substrates by Gas Chromatography
褚佳玥 1胡守江 1张益萍1
作者信息
- 1. 上海市质量监督检验技术研究院,上海 200233
- 折叠
摘要
建立气相色谱法检测不同基质化妆品中角鲨烷的定量方法.将不同产品用正己烷和少量水振荡提取,分流比为1∶5,线性相关系数(r)＞0.999,角鲨烷质量浓度在 10～500 μg/mL范围内具有良好的线性关系,方法检出限为30 mg/kg、定量限为100 mg/kg.基质为水的化妆品中,角鲨烷加标回收率为100.3%～104.1%;乳状基质的化妆品中,角鲨烷加标回收率为100.6%～104.6%;霜状化妆品中,角鲨烷加标回收率为100.9%～103.1%;相对标准偏差(RSD)均＜1.5%(n=7).随机选取市场采购的化妆品进行检测,测量值与已知结果接近,这些结果都证明了该方法满足了检测3种基质化妆品的精密度和准确度要求.
Abstract
A quantitative method for the determination of squalane in cosmetics with different substrates by gas chromatography was established.Different products were extracted by oscillating with n-hexane and water,the split ratio was 1:5,the linear correlation coefficient(r)＞0.999,and the mass concentration of squalane had a good linear relationship in the range of 10-500 μg/mL.The detection limit of the method was 30 mg/kg,and the quantification limit was 100 mg/kg.The recoveries of squalane with water as the base were 100.3%-104.1%.The recoveries of squalane with emulsion matrix were 100.6%-104.6%.The recoveries of squalane in cream cosmetics ranged from 100.9%to 103.1%.Relative standard deviations(RSD)was less than 1.5%(n=7).Cosmetics purchased from the market were randomly selected for testing,and the measured values were close to the known concentration results,which all proved that the method met the precision and accuracy requirements for testing cosmetics with three substrates.
关键词
化妆品/角鲨烷/气相色谱法Key words
cosmetics/squalane/gas chromatography引用本文复制引用
基金项目
化妆品中角鲨烷的检测方法研究项目(2022-54)
出版年
2024
NETL
NSTL
万方数据