皮肤衰老是衰老研究领域的一个分支,生物标志物可用于客观评价皮肤衰老程度,包括了特定蛋白基因、信号通路的激活以及一系列细胞分泌因子.本文概述了皮肤衰老相关分泌表型(skin aging related secretion phenotype,SASP)的组成及其生理功能、SASP在皮肤衰老过程中的变化,以及针对SASP为功效靶点设计的化妆品功效测试组合方法,旨在对基于SASP靶点的相关功效化妆品研究有一个更加全面深刻的认识.
Review on the Mechanism of Skin Aging Related Secretion Phenotype and Related Functional Ingredients
Skin aging is a branch of aging research.Biomarkers can be used to objectively evaluate the degree of skin aging,including specific protein genes,activation of signaling pathways,and a series of cell secretion factors.The composition and physiological functions of skin aging related secretion phenotype(SASP)were described in this paper,its changes during skin aging,and cosmetic efficacy testing combination methods designed for SASP as a efficacy target.The aim is to provide a more comprehensive and profound understanding of research on related efficacy cosmetics based on SASP.
skinsenescenceskin aging related secretion phenotype(SASP)anti-aging
NETL
NSTL
万方数据
