In Vitro Transdermal Effect of Hydroxypinacol Retinoate Nanostructured Lipid Carrier
The hydroxypinacol retinoate-nanostructured lipid carrier(HPR-NLC)was prepared by the microemulsion method.In vitro transdermal experiments were carried out on the HPR-NLC using in vitro pig skin and Franz diffusion cell permeation device,and the transdermal effect was compared with that of HPR non-inclusion.The mass concentration of HPR in the receiving solution was determined by liquid chromatography at different times.The cumulative transmittances were calculated.The transdermal absorption effects of HPR samples in two different processes were evaluated by the cumulative transmittance-time curve.The retention of HPR in pig skin was also detected.The results showed that the nanostructured lipid carrier was more favorable to the HPR permeation,and the cumulative HPR permeation in the nanostructured lipid carrier was 26.48 μg/cm2 at 24 h,which was 9 times that of the non-inclusion.The average retention of HPR in pig skin was 4.32 μg/cm2,which was 6.5 times that of the non-inclusion.
万方数据
维普
