In order to screen suitable auxiliary pro-osmotic agents to improve the pro-osmotic ability of Camellia japonica oil,effects of Camellia japonica oil on the in vitro transdermal absorption of the active substances in emulsions were investigated by using in vitro modified Franz diffusion cell method.The isolated porcine skin as a model.Then high performance liquid chromatography(HPLC)and gas chromatography(GC)were used to quantitatively analyze the transdermal accumulations and intradermal retentions of tea polyphenols and 1,3-butanediol.The results showed that 3%(mass fraction)of Camellia japonica oil in the emulsion had the optimal permeation promoting ability,0.5%(mass fraction)of ethoxydiglycol improved the permeation promoting effect of Camellia japonica oil on the actives,and the addition of a certain concentration(≥0.5%,mass fraction)of lauric azadirachtinone inhibited the permeation promoting effect of Camellia japonica oil.Ethoxydiglycol,which had a different osmotic mechanism with Camellia japonica oil,could be used as an auxiliary osmotic agent to improve the osmotic effect of Camellia japonica oil.
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