Comparison of in Vitro Skin Models of Rats,Guinea Pigs,Rabbits and Pigs in the Evaluation of Exfoliation Efficacy
By comparing the tissue structure of in vitro skin models of rats,guinea pigs,rabbits and pigs,their applicability in the evaluation of cosmetic exfoliation efficacy were evaluated.After treatment with exfoliating scrub,four animal skin models were stained with hematoxylin-eosin staining(HE)and examined under the microscope.It was observed that the Stratum corneum presented different histological morphology.The Stratum corneum of the blank control was uniformly distributed in a strip shape on the epidermis,arranged relatively tightly,and there was no obvious detachment or detachment of the Stratum corneum.The skin model of the experimental group was observed to have a loose,detached and thinned outer layer of the Stratum corneum.These observations indicates that different animal skin models may differ in the changes in the Stratum corneum,but all four animal in vitro skin models can be used as options for evaluating the exfoliation efficacy of cosmetics.
in vitro skin modelexfoliationhistologyefficacy evaluation
万方数据
维普
