Preparation of Active Salicylic Acid by Solid-State Heating and Grinding Method and Its Structure Characterization
A ternary complex of betaine and matrine encapsulated salicylic acid was prepared by solid-state heating and grinding method.w(salicylic acid)∶w(betaine)∶w(matrine)=1∶15∶1.7 was selected as the optimized proportion.It had good water solubility and the pH value of the 1%(in mass fraction)active salicylic acid solution was 4.7.The solubilizing effects of betaine and matrine on salicylic acid in active salicylic acid studied through nuclear magnetic resonance(NMR)and infrared spectrosopy(IR).Salicylic acid could be connected through carboxyl and hydroxyl groups with the carboxyl group of betaine,as well as the carbonyl and tertiary amine nitrogen of matrine through hydrogen bonding,greatly improving the solubility of salicylic acid.
active salicylic acidsalicylic acidbetaine matrinenuclear magnetic resonance(NMR)infrared spectroscopy(IR)
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