The technical gist of modeling process in single sodium lauryl sulfate(SLS)stimulation and tape stripping short-term model was studied in this paper.By using SLS solutions with different mass fractions and stimulated one forearm under closed conditions for 24 h,skin transdermal water loss(TEWL)and skin erythema index(EI value)were measured at 1,2,4,6,24,48,72 h after the patch was removed.Take three 3 cm×3 cm areas from the other arm and perform different degrees of tape stripping.Record the parameter values of before stripping,immediate(Tim),2 h,4 h after stripping.The results showed that for a single SLS stimulation model,when the mass fraction of SLS solution was 1%,EI values reached the maximum value after 24 h.When the mass fraction of SLS solution was 2%,after 24 h,both TEWL and EI values reached their maximum value.For the tape stripping model,EI values increased significantly after 4 h.Therefore,it was not mean that the more severe the barrier damage,the better the short-term models.The experimental design should be considered based on the product's mechanism of action and the test purpose.
关键词
十二烷基硫酸钠/胶带剥离/经皮失水流失/红斑指数
Key words
sodium dodecyl sulfate/tape stripping/transepidermal water loss/erythema index
维普
万方数据