Preparation of Azelaic Acid-Chitosan Gel and Its Release Characteristics in vitro
Homogeneous,transparent and stable gel containing azelaic acid was successfully prepared by chitosan,tromethamine and specific polyol solvent system at pH 5.0-6.0.Through systematic research on the mass ratio of azelaic acid and chitosan,the type and content of polyols,pH range and the type of pH regulator,the content of azelaic acid in the system was increased to 20%(in mass fraction).The 10%azelaic acid gel was selected to characterize the structure and study its release performance in vitro.The combined analysis of infrared spectroscopy(IR)and thermogravimetric-differential scanning calorimetry(TG-DSC)showed that azelaic acid underwent a salt formation reaction.The in vitro release test results showed that azelaic acid in the gel had excellent release performance.The release rate was(3 193.61±75.45)μg/(cm2·min1/2)and the accumulated release rate was(86.46%±3.04%)after 150 min.The azelaic acid gel prepared in this study significantly improves the bioavailability of azelaic acid.
azelaic acidchitosantromethaminegelrelease in vitro
万方数据
维普
