Determination of 45 Elements in Children's Makeup by ICP-MS/MS
A method for the determination of 45 elements in children's makeup by inductively coupled plasma tandem mass spectrometry(ICP-MS/MS)was established.The results showed that 45 elements had good linear relationship within their respective mass concentration ranges,with correlation coefficients greater than 0.991 7.At the 2 spiked levels,the average recoveries in 3 matrices of cream,powder and lipstick were 80.1%-116.5%,80.6%-118.3%,and 84.5%-113.4%,respectively,and the average relative standard deviations(RSDs)were 0.6%-6.9%,0.8%-8.9%,and 1.3%-5.2%,respectively.This method supplements and optimizes the determination methods in Safety and Technical Standards for Cosmetics(2015)and solves the problems of specificity,accuracy and stability in the determination of multiple elements in children's makeup,and compensates for the shortcomings of incomplete coverage of element types and inconsistent detection methods in existing standard methods.It is of great significance for the quality control of children's makeup products.