化学剥脱术后舒缓修护人体功效评价模型的构建

Construction of a Model for Evaluating the Soothing and Repairing Effects on the Human Body after Chemical Peeling

王思艺 ¹权强华 ¹周明 ¹杨伶俐 ¹潘海浩 ¹杨杨 ¹叶琳洋 ²熊俊 ²翟文丽¹

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作者信息

1. 云南白药集团上海科技有限公司,上海 201107;云南白药集团健康产品有限公司,北京 100048;睿迩检测技术有限公司,北京 100048
2. 睿迩检测技术有限公司,北京 100048
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摘要

化学剥脱后皮肤会出现红斑、干燥、敏感等,此时进行皮肤护理可缓解副作用、促进皮肤恢复.水杨酸和乙醇酸剥脱后 4 h内出现皮肤红斑指数(EI)和经皮水分散失(TEWL)增加.招募 30 受试者建立化学剥脱皮肤舒缓修护模型,乙醇酸组在1、2、3 h出现EI升高(P＜0.05),2 d出现TEWL升高(P＜0.05).用具有舒缓、修护功效的产品进行干预,EI和TWEL均降低,副作用得到缓解,部分时间点空白组与阳性组间指标变化量具有统计学差异(P＜0.05).因此,乙醇酸化学剥脱模型可作为一种安全、稳定、高效的人体功效评价手段,协助化学剥脱后舒缓修护类护肤产品的开发.

Abstract

After chemical peeling,the skin may experience side effects such as erythema,dryness,and sensitivity.At this time,skin care can alleviate the side effects and promote skin recovery.An increase in erythema index(EI)and transepidermal water loss(TEWL)was observed within 4 h after salicylic acid and glycolic acid peeling.Then 30 subjects were recruited to establish a model of soothing and repairing chemically peeled skin.The glycolic acid group showed increased EI at 1,2,3 h(P＜0.05),and increased TEWL at 2 d(P＜0.05).Intervention with products with soothing and repairing effects reduced both EI and TEWL,and the side effects were alleviated.The changes in indices between the blank and positive groups at some time points had statistical differences(P＜0.05).Therefore,the glycolic acid chemical peeling model can serve as a safe,stable,and effective human efficacy evaluation method to assist in the development of soothing and repairing skincare products after chemical peeling.

关键词

化学剥脱术/舒缓/修护/人体功效评价

Key words

chemical peeling/soothing/repairing/human body efficacy evaluation

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出版年

2024

香料香精化妆品

上海香料研究所

香料香精化妆品

CSTPCD

影响因子：0.341

ISSN：1000-4475

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