A method of ultra-performance liquid chromatography-high resolution mass spectrometry(UPLC-ESI-Q-TOF/MS)matching database screening for detecting banned antibiotic components in cosmetics was established.A compound database,for antibiotics that may be added in cosmetics,was established.All compounds were classified according to their structural characteristics,sorted by their oil-water partition coefficients(log P value),and representative substances were selected to form a compound set to develop the UPLC-ESI-Q-TOF/MS analysis method.Sample screening is performed by the first-and second-degree precise mass number of the mass spectrometry in comparison to standards,while quantification is based on the first-degree mass response.The method is fast and efficient,and can quickly complete the rapid screening of 296 antibiotics from ten categories in cosmetics,even in the absence of 90%of the controls.
关键词
化妆品/抗生素/超高效液相色谱-高分辨质谱联用仪/数据库
Key words
cosmetics/antibiotics/ultra-performance liquid chromatography-high resolution mass spectrometry(UPLC-ESI-Q-TOF/MS)/database
维普
万方数据