Correlation Between Surface Activity and Cytotoxicity of Polyols Commonly Used in Cosmetics
The surface activities and cytotoxicities of 1,3-propanediol,1,3-butanediol,dipropanediol,glycerol,diglycerol,1,2-pentanediol and 1,2-hexanediol were studied,and the correlations between the surface activity and cytotoxicity of these 7 polyols were investigated.The results showed that the surface activities and cytotoxicities of the same polyol were positively correlated with their concentrations.Under the same concentration,the surface activity of 1,2-hexanediol was the highest,and the cytotoxicities of 1,2-pentadiol and 1,2-hexanediol were similar and significantly higher than other polyols.The cytotoxicity data of glycerol and diglycerol were similar,and both showed good biocompatibility.The change range of the surface activity of diglycerol was the narrowest within the test concentration.Except glycerol,the curve fitting correlations between surface activity and cytotoxicity of the other 6 polyol aqueous solutions were good,that was,the higher the surface activity of polyol,the higher the cytotoxicity,and they were positively correlated.
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