The shared vulnerability relationship between creativity and the schizophrenia spectrum:Personality,cognition,and neurobiological research
Whether high creative people are more likely to suffer from schizophrenia spectrum diseases is a research hotspot.There is an inverted U-shaped relationship between creativity and schizophrenia,and the shared vulnerability modelcan help explain the relationship between them.Specifically,psychoticism and schizotypy are the personality traits associated with creativity in schizophrenic pedigree disorder.Excessive inclusive thinking and low cognitive inhibition may be the cognitive processing characteristics associated with schizophrenia spectrum disorder and creativity.The related brain structures include the decrease of forebrain gray matter volume,the decrease of FA value of subfrontal white matter fibers and the variation of cingulate cortex structure;The similarity of brain function includes the obvious activation of frontal lobe and cingulate gyrus,the activity of Default Mode Network and the decrease of cerebral hemisphere asym-metry.Polygenic risk score(PRS)showed that there is significant positive gene overlap between creativity and schizophrenia.The receptor molecules involve gene polymorphism of dopamine system and serotonin system gene.Future research should further focus on specific cognitive mechanism and neuroscience mecha-nism,expand the field of creativity and the selection of creativity measurement tools,strengthen the ex-ploration of the rehabilitation intervention plan of schizophrenic patients with creativity activities,and carry out further research,improvement and revision according to the actual situation of China.
万方数据
维普
