Clinical effect analysis of treating primary lung cancer with a pattern of spleen deficiency and phlegm stasis by Ciji-Hua'ai-Baosheng Ⅱ formula combined with conventional western medicine
[Objective]This study aims to investigate the clinical effect of Ciji-Hua'ai-Baosheng Ⅱ formula combined with conventional western medicine in the treatment of patients with primary lung cancer with a pattern of spleen deficiency and phlegm stasis.[Methods]Based on the real-world study(RWS)method,65 patients with primary lung cancer and a pattern of spleen deficiency and phlegm stasis,diagnosed and treated at the inpatient oncology department of Xiamen Hospital of Traditional Chinese Medicine and the outpatient department of Xiamen Yanlaifu National Medical Center from November 2019 to December 2020 were collected.Patients were classified into a control group that received only western medicine treatment(chemotherapy,radiotherapy,targeted therapy)and an experimental group that received western medicine treatment combined with Ciji-Hua'ai-Baosheng Ⅱformula treatment.Karnofsky performance status(KPS)scores,traditional Chinese medicine(TCM)syndrome total scores,tumor-related markers[carcinoembryonic antigen(CEA),squamous cell carcinoma(SCC),neuron-specific enolase(NSE),and cytokeratin-21-fragment(Cyfra21-1)],toxic and side effects,safety indicators[blood routine(white blood cells,platelet counts,and hemoglobin concentration),and liver and kidney function(alanine aminotransferase,aspartate aminotransferase,urea,blood creatinine)]were compared between the two groups before and after treatment.SPSS 23.0 statistical software was used for the statistical analysis of the collected patient data.[Results]Before treatment,there was no statistical difference in baseline demographics,laboratory test results,or disease-related clinical symptoms between the two groups(P＞0.05),indicating comparability between the two groups.After treatment,KPS scores in both groups were higher than before treatment(P＜0.05),with the difference before and after treatment in the experimental group being 5.45±7.11,compared to 3.44±6.53 in the control group,indicating that the improvement in the experimental group was significantly better than that in the control group.The TCM syndrome total scores decreased in both groups(P＜0.01),with a reduction of 4.48±2.82 in the experimental group and 2.25±2.99 in the control group,indicating that the improvement in the experimental group was significantly stronger than that in the control group.The P values of each single symptom(cough,expectoration,shortness of breath,chest tightness,fatigue and weakness,loss of appetite,upset,and insomnia)before and after treatment in the experimental group were all less than 0.05,suggesting a significant treatment effect.In the control group,significant improvement was observed in cough,expectoration,shortness of breath,chest tightness,and chest pain,but not in fatigue and weakness,loss of appetite,or upset and insomnia.There were no significant differences in liver and kidney function and tumor markers between the two groups before and after treatment.However,before and after treatment,platelet and hemoglobin mass concentration in the control group decreased significantly(P＜0.05),indicating that myelosuppression was more serious in the control group than in the experimental group.[Conclusions]The combination of Ciji-Hua'ai-Baosheng Ⅱ formula and western medicine in treating primary lung cancer with a pattern of spleen deficiency and phlegm stasis can improve the clinical symptoms of patients,especially sleep,diet and physical strength of patients,enhance the quality of life,reduce the toxic side effects associated with western medicine alone,and have good therapeutic effect and safety.
Ciji-Hua'ai-Baosheng Ⅱ formulaclinical researchChinese-western medicine combined therapyprimary lung cancerspleen deficiency and phlegm stasis pattern
国家科技期刊平台
NSTL
万方数据
