Application value of dermoscopy in the diagnosis of adult xanthogranuloma
[Objective]Adult xanthogranuloma(AXG)is a benign,cutaneous proliferative disorder of histiocytes and is a type of granulomatous process.Currently,histopathological findings are the gold standard for diagnosing AXG.Tissue pathological biopsy is generally traumatic,causing patients to experience pain,scars,and low compliance,which can lead to missed diagnosis and misdiagnosis.With the development of technology,dermoscopy has emerged as a new auxiliary examination and diagnostic method in dermatology clinical practice.It is gaining popularity due to its convenient use,non-invasiveness,and improved diagnostic accuracy,making it useful for the evaluation of AXG.The classical"setting sun"pattern is characteristic of XG,but its sensibility appears to be limited.An extensive description of other dermoscopic findings is not available in the literature.This study aimed to valuate and describe the clinical and dermoscopic characteristics of a series of AXG cases.[Methods]This is a retrospective descriptive study,including cases with histopathologic diagnosis of AXG,along with the availability of clinical and dermoscopic images.The cases were assessed for the presence of dermoscopic features based on the available literature.Dermoscopic examination was performed on 29 suspected lesions of 29 cases of suspected AXG by dermoscopic doctors,following clinical diagnosis by experienced dermatologists.At the same time,histopathological examination was conducted on the lesions,and the diagnostic results were compared.[Results]Among the 29 suspected lesions,24 were diagnosed by dermoscopy,and 25 were diagnosed by histopathology.Taking histopathology as the gold standard,the sensitivity of dermoscopy was 96％,and the specificity was 100％.The dermoscopic features of AXG patients all showed a setting sun sign,followed by linear and/or branched vessels(96％,24/25).The most common dermoscopic patterns were the setting sun sign+linear and/or branched vessels(68％,17/25),followed by the setting sun sign+linear and/or branched vessels+bright white streaks(28％,7/25),and setting sun sign+bright white streaks(4％,1/25).[Conclusions]This study reveals that AXG exhibits distinct dermoscopic signatures,particularly the setting sun sign,along with other specific vascular patterns.These findings highlight the value of dermoscopy as a complementary diagnostic tool in the identification and differentiation of AXG.The high sensitivity and specificity demonstrated by dermoscopy suggest that it can serve as a valuable adjunctive method for the diagnosis of AXG,allowing for more accurate and prompt identification of the condition,thereby potentially improving patient management and treatment outcomes.Due to its non-invasive nature and the ability to provide real-time,detailed visualization of skin structures,dermoscopy proves to be a reliable means for the early recognition of AXG,reducing the need for invasive biopsies and enhancing overall diagnostic accuracy in the field of dermatology.
国家科技期刊平台
NSTL
万方数据
