A SNPs Variation Map of LCORL Gene among Global Sheep Breeds Based on Whole-genome Resequencing
The LCORL gene is an important gene that influences the growth rate and body size of sheep.Constructing a com-prehensive genetic variation map of this gene will help systematically assess its correlation with sheep growth traits and identify growth-related variation sites.However,no study has systematically screened the single nucleotide polymorphisms(SNPs)of this gene in different sheep breeds.In this study,based on whole-genome resequencing data from 1 615 sheep across 27 domestic and international breeds,4 777 high-confidence SNPs were identified,including 16 mutations in coding regions,with 10 missense mutations and 6 synonymous mutations.Additionally,this study found that one missense mutation(g.38075364G＞A)is under selection in large-bodied Dorper sheep,suggesting that this site may be related to sheep growth traits.This study constructed a genetic variation map of the LCORL gene in sheep,providing valuable resources for exploring mutations and genetic markers related to sheep growth traits.
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