Objective To research the changes in thyroid,blood lipid metabolism and cardiac function in coronary heart disease (CHD) patients with hypothyroidism.Methods A total of 180 patients admitted in our hospital were divided into a research group and a control group (CHD with hypothyroidism and CHD only,n =90,respectively).The serum samples in two groups were collected to detect the thyroid function and serum lipid levels,and the differences in cardiac function were detected between the two groups according to echocardiography.Results The levels of serum free triiodothyronine three (FT3) and free thyroxine (FT4) in the research group were lower than those in the control group,and serum thyroid stimulating hormone (TSH) was significantly higher than that in the control group,with significant differences between the two groups (P ＜ 0.05).There was no difference in high-density lipoprotein (HDL-C) (P ＞ 0.05) between the two groups;the levels of total cholesterol (TC),triglyceride (TG) and low-density lipoprotein (LDL-C) in the research group were higher than those in the control group,and there were significant differences between the two groups (P ＜0.05).There was no significant difference in the ratio of left ventricular early-diastolic mitral flow velocity to the end-diastolic velocity (E/A) in the two groups(P ＞ 0.05);the left ventricular ejection fraction (LVEF) in the research group was lower than that in the control group,and the left ventricular mass index (LVMI) and left ventricular end-diastolic diameter (LVDd) were higher than those in the control group high(P ＜ 0.05).Conclusion Abnormal blood lipid metabolism and severely damaged cardiac function exist significantly in CHD patients with hypothyroidism.Clinically,CHD patients should receive thyroid-related examination and scientific treatment plan should be prepared in order improve the prognosis.
coronary heart diseasehypothyroidismserum lipidcardiac function
国家科技期刊平台
NSTL
维普
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