Objective To observe the effect of dexmedetomidine on hemodynamics and inflammatory tactors of patients with lung cancer during thoracoscopic perioperative period.Methods 60 patients with lung cancer receiving thoracoscopic surgery were selected and divided randomly and equally into DEX group (group A) and control group (group B).Group A received intravenous infusion of DEX loading dose of (0.8 μg/kg) for 15 min before anesthesia induction,and then to continuous infusion at the rate of 0.6 μg/(kg ·h) until the end of the operation before 30 min.Group B were given an equal volume of saline as group A.The hemodynamic parameters,changes of inflammatory factors(TNF-α and IL-6),and incidence of adverse reactions in perioperative period were observed in the two groups.Results Compared with the group B,the mean arterial pressure and heart rate of group A were significantly decreased at each time point,and the expression level of inflammatory factors TNF-α and IL-6 in blood also decreased (P ＜ 0.05).The number of postoperative agitation and shivering cases occurred in group A was significantly less than that in group B (P ＜ 0.05).Conclusions The application of dexmedetomidine in thoracoscopic surgery for lung cancer can maintain the hemodynamic stability,inhibit the release of inflammatory factors and significantly reduce the incidence of the perioperative adverse reactions.
国家科技期刊平台
NSTL
维普
万方数据
