Objectivo To explore the clinical value of sequential lauromacrogol injection of fibrinogen and thrombin in the treatment of gastric fundus varices bleeding.Methods A total of 152 patients with gastric fundus varices bleeding were randomly divided into two groups (n =76,respectively).The treatment group received sequential lauromacrogol injection of fibrinogen and thrombin and the control group received tissue adhesive (α-cyanoacrylates) (sandwich method).The success rate of hemostasis,the damage from instruments,the rate of rebleeding,venous improvement,and the complications were compared.Results The success rate of hemostasis in the two groups was 98.68％ and 93.42％,respectively,without significant difference (P ＞ 0.05);the incidence of rebleeding was 4.00％ and 25.35％,respectively,with a significant difference between the two groups (P ＜ 0.01).The incidences of fever,abdominal pain adverse reaction were similar between the two groups (P ＞ 0.05),but the incidence of ulcer in the control group was higher than that in the treatment group (P ＜ 0.05),so did the incidences of stuck needle and endoscope (P ＜ 0.01).There were no serious complications such as ectopic embolization in the two groups.Conclusion Sequential lauromacrogol injection of fibrinogen and thrombin has good hemostatic effects and low bleeding rate,is safe and reliable.
国家科技期刊平台
NSTL
维普
万方数据
