Objective To explore the relationship between the levels of serum resistin,oxidized low-density lipoprotein(ox-LDL) and matrix metalloproteinase-9 (MMP-9) and carotid artery plaque in senile patients with acute cerebral infarction (ACI).Methods A total of 120 senile patients suffering ACI to receive treatment in our hospital were divided into normal-IMT group and plaque group (n =60,respectively) according to the carotid intima-media thickness (IMT),and another batch of persons in normal healthy condition were selected to constitute a health group (n =30).Enzyme-linked immunosorbent assay (ELISA) was adopted for determining the levels of serum resistin,ox-LDL and MMP-9.Results Compared with those in the plaque group and the health group,the TC,TG,and HDL-C in the normal-IMT group has no significant differences (P ＞ 0.05);the BMI,TC,and TG in the plaque group were significantly higher than those in the health group,while the HDL-C was significantly lower than that in health group (P ＜ 0.05).The average levels of serum resistin,ox-LDL and MMP-9 in the plaque group were significantly higher than those in the normal-IMT group and the health group(P ＜ 0.05),and those in the normal-IMT group were significantly higher than those in the health group (P ＜ 0.05).Spearman correlation analysis showed that in the plaque group the serum resistin and ox-LDL kept a positive correlation with the MMP-9 and serum resistin kept a positive correlation with the ox-LDL.Conclusion The serum resistin,ox-LDL and MMP-9 can reflect the severity of carotid artery plaque in senile patients ACI,so they can be used as an important reference index in the diagnosis on senile carotid artery plaque.
国家科技期刊平台
NSTL
维普
万方数据
