Objective To observe and compare the effects of acute normovolemic hemodilution (ANH) and acute hypervolemic hemodilution (AHH) on hemodynamics in senile patients undergoing orthopedics surgery.Methods A total of 60 senile patients to undergo orthopedics surgery were divided into ANH group and AHH group.After anesthesia,the two groups received ANH and AHH respectively.The changes in systolic blood pressure (SBP),diastolic blood pressure (DBP),central venous pressure (CVP),and heart rate (HR) and other hemodynarnic indicators in the two groups were observed at different time points.Results The SBP,DBP,CVP and HR in the two groups were stable,and there was no significant difference between the two groups at the time points (P > 0.05).There was no statistical difference in intraoperative blood loss between the two groups (P > 0.05).The intraoperative blood transfusion in the ANH group was significantly less than that in the AHH group (P < 0.05).Conclusion Both hemodilution methods can maintain stable hemodynarnics in senile patients undergoing orthopedics surgery,but ANH method is better than AHH method,for it can reduce the amount of blood transfusion significantly and reduce adverse reaction after allogenetic blood transfusion.