Objective To explore the effects of bisoprolol combined with conventional therapy on chronic pulmonary heart disease associated with coronary artery lesions.Methods A total of 78 patients with chronic pulmonary heart disease associated with coronary artery lesions admitted to our hospital were selected and divided into a conventional group and a combination group (n=39,respectively).The two groups received conventional treatment,and additionally,the combination group was treated with bisoprolol.The ECG QTD,vascular endothelial functions [ET,TXB2 and NO] and cardio-pulmonary functions [LVEF,LVEDD,FVC,and FEV1] before and after the treatment between the two groups were compared.Results Before the treatment,the QTd and cardio-pulmonary functions in the two groups showed no significant difference (P ＞ 0.05);after the treatment,the QTd in the two groups shortened significantly,LVEF increased greatly,LVEDD,ET and TXB2 decreased greatly,and NO increased significantly;the FVC and FEV1 in the conventional group decreased significantly(P ＜ 0.05).The improvement of QTd and cardio-pulmonary functions in the combination group was greater than that in the conventional group (P ＜ 0.05).Conclusion Bisoprolol combined with conventional therapy can significantly shorten the QTd in patients,protect vascular endothelial function and pulmonary function,and effectively improve cardiac function.
chronic pulmonary heart diseasecoronary artery lesioncardio-pulmonary functionvascular endothelial function
国家科技期刊平台
NSTL
维普
万方数据
