Objective To explore the influences of BK virus (BKV) infection on the long-term prognosis of renal transplant recipients.Methods A total of 182 patients who received renal transplantation in our hospital were selected.According to the regular re-examination one year after the transplantation,the patients with post-operative BKV infection were selected as an observation group and those without BKV infection as a control group.The use of immunosuppressant was adjusted in the observation group and the treatment effects were followed up.The long term survival rate and the changes in renal function indexes of transplanted kidney between the two groups were compared.Results (1)71 patients had BKV infection(BKV urine disease) and five patients had BK virus associated nephropathy (BKVAN) after the operation.After the adjustment of immunosuppressant use,58 (81.7％) of the patients with BKV urine disease turned to negative,the turning negative time was (12.8±1.4)months,and two (40.0％) of the patients with BKVAN turned to negative.(2)There was no statistical difference in the survival rate of transplanted kidney and the function of transplanted kidney in the fifth year between BKV urine disease patients and non-BKV urine disease patients (P ＞ 0.05).Conc lusion After the adjustment of immunosuppressant use,the response to the treatment among patients with BKV infection is good.The long-term influences of BKV urine disease on the long term survival rate and renal function of transplanted kidney can be avoided.
国家科技期刊平台
NSTL
维普
万方数据
