Objective To analyze the effects of endoscopic mouth floor approach combined with central lymph node dissection of thyroid carcinoma.Methods A total of 88 patients with thyroid carcinoma were randomly divided into group A and group B.The two groups received e ndoscopic thyroidectomy via breast approach,and group A was additionally treated with mouth floor approach combined with central lymph node dissection on the basis of group B.The count of lymph nodes dissected,incidence of complication and recurrence rate during two-year follow-up vision between the two groups were compared.Results The count of central lymph nodes dissected in group A 7.52±1.46 was more than that in group B 6.15±1.14 (P < 0.05);the oral infection rate in group A was 8.89%;there was no significant difference in the incidence of intraoperative blood loss,length of stay (LOS),transient hoarseness and temporary injury of recurrent laryngeal nerve between the two groups (P > 0.05);the recurrence rate within two years after the operation in group A was significantly lower than that in group B (P < 0.05).Conclusion Compared with simple endoscopic thyroidectomy via breast approach,mouth floor approach combined with central lymph node dissection can dissect the central lymph nodes more thoroughly;the recurrence rate two years after the operation is lower;except for oral infection risk,the incidence of complication does not increase.