Objective To explore the value of 128-layer spiral CT perfusion imaging in angiogenesis and neo-adjuvant chemotherapy of cervical cancer.Methods A total of 86 patients with cervical cancer admitted to our hospital were selected as study subjects,among which 45 ones received direct surgical treatment and 41 ones received neo-adjuvant chemotherapy.The CT perfusion imaging parameters and the correlation with angiogenesis in patients with different pathological types and the CT perfusion imaging parameters in patients before and after neo-adjuvant chemotherapy and with different clinical effects were compared.Results The blood flow (BF),blood volume (BV) and permeability surface of the patients with squamous carcinoma were significantly higher than those of the patients with adenocarcinoma,and the mean transit time (MTT) of contrast medium was much shorter than that of the patients with adenocarcinoma;the BF,BV and PS of the patients with high FIGO staging,low differentiated degree and positive lymph node metastasis were higher than those of the patients with low FIGO staging,high differentiated degree and negative lymph node metastasis,with the MTT significantly shorter (P ＜ 0.05).In CT perfusion imaging,BF,BV and PS were positively correlated with microvessel density (MVD),while MTT was negatively correlated with MVD (P ＜ 0.05).After neo-adjuvant chemotherapy,the BF,BV and PS of the patients decreased significantly,but MTT increased significantly;the BF,BV and PS in the clinically effective group were higher than those in the ineffective group,but MTT was shorter than that in the ineffective group (P ＜ 0.05).Conclusion 128-layer spiral CT perfusion imaging can provide tumor information from hemodynamics and has significant value in the analysis of cervical cancer angiogenesis and effects of neo-adjuvant chemotherapy.
国家科技期刊平台
NSTL
维普
万方数据
