Preparation of magnetic polymer micelles and their drug release behavior
Cancer,a notoriously incurable disease,is primarily treated through chemotherapy,radiotherapy,and surger-y.Chemotherapy often employs hydrophobic small-molecule drugs,which exhibit limited circulation in body fluids and rapid me-tabolism,potentially compromising therapeutic efficacy.To overcome these challenges,magnetic nanoparticles(NPs)coated withβ-CD(CD-MNPs)and ferrocene-modified polymers(mPEG-Fc and PNIPAM-Fc)were developed.Utilizing the host-guest recog-nition between β-CD and ferrocene,polymer chains were constructed with varying hydrophobicity on the surface of the magnetic NPs.By adjusting temperature,the particle surface exhibited amphiphilic properties,self-assembling into spherical micelles with a diameter of approximately 250 nm.This assembly system could be reversibly formed and disintegrated by temperature modula-tion.Notably,when loaded with the anticancer drug DOX,these micelles exhibited an encapsulation rate of 73％and a drug loading capacity of 13％,demonstrating a favorable sustained release profile.The results suggested that this magnetic polymer micelle,exhibiting excellent stability,high drug encapsulation,and loading capacities,held promising potential for application in drug delivery and release systems.
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