Research progress of mechanisms in CD44 mediated chemoresistance by coding/Non-coding genes in various tumors
Long term drug-resistant cells significantly enhance tumor metastasis and induce CD44 protein expression in multiple cancer types(pancreatic cancer,lung cancer,colorectal cancer,etc.).CD44 is a non-kinase receptor that plays an important role as a tumor stem cell marker in invasion and metastasis of various tumors.A combination of first-line chemotherapeutic drugs and CD44-targeted drugs at an early administration time point may improve the overall survival rate of advanced metastasis of cancer patients.This review summarized the mechanisms of tumor resistance and metastasis mediated by CD44 protein from its upstream regulators such as coding genes(transcription factors,hetero-ribonucleoproteins,epithelial splicing regulatory pro-teins,cytokines,and protein kinases)and non-coding genes(lncRNA,miRNA,and circRNA).In addition,CD44 isoform switch,CD44 gene regulation,CD44 downstream signaling pathways mediated cancer cells drug-resistance,and the clinical sig-nificance of CD44 as a cancer therapeutic target were also summarized.
CD44drug resistancecancerlong non coding RNAgene regulation
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维普
