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基于数据挖掘探讨国医大师黄瑾明治疗不孕症的用药规律

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国医大师黄瑾明治疗不孕症有较丰富的用药经验。从文献和医案中筛选出国医大师黄瑾明治疗不孕症的方剂60首,构建国医大师黄瑾明治疗不孕症方剂数据库,并应用SPSS软件对处方信息进行频数分析、聚类分析、复杂网络分析、关联规则分析,统计其治疗不孕常用药物出现的频次、性味、功效范围以及常见药物组合,归纳黄瑾明教授治疗不孕症的用药规律。国医大师黄瑾明认为不孕症的发生是由于道路功能失调、毒邪阻滞道路或道路气血瘀滞致使咪花肠(子宫)气血瘀滞、功能失调所致,因此遣方用药多从通调三道两路、恢复道路功能出发。道路功能失调多用甘甜平温的调气通路类、补虚通路类药物;毒邪阻滞道路多用辛辣温热或味苦寒凉的调气通路类、解毒通路类药物;而道路气血瘀滞多用辛辣温热的祛瘀通路类药物;用药频次居多的为当归、菟丝子、枸杞子、补骨脂、熟地黄等20味药物,核心药物组合是菟丝子-枸杞子,常用药物组合有枸杞子→菟丝子、巴戟天→淫羊藿-菟丝子、枸杞子→巴戟天-淫羊藿-菟丝子等,是黄氏壮医滋水补阴汤、黄氏壮医温水补阳汤、黄氏壮医补谷健脾汤、黄氏壮医调气解毒散结汤、黄氏壮医祛瘀通经汤等黄氏壮医经验方的主要药物及药物组合,在不孕症的临床治疗上可根据辨证灵活使用,以期为不孕症的壮医临床用药和科研提供指导与借鉴。
Discussion on the medication rule of National Medicine Master Huang Jinming in the treatment of infertility based on data mining
National Medicine Master Huang Jinming has rich experience in treating infertility.From the literature and medical records,60 prescriptions for treating infertility by National Medicine Master Huang Jinming were selected,and the database of prescriptions for the treatment of infertility by National Medicine Master Huang Jinming was constructed.SPSS software was used to perform frequency analysis,cluster analysis,complex network analysis,and association rule analysis on the prescription infor-mation.The frequency,flavor,efficacy range,and common drug combinations of the commonly used drugs for the treatment of in-fertility were counted,and the medication rules of the Master for the treatment of infertility were summarized.Huang believes that the occurrence of infertility is due to the dysfunction of the road,the blockage of the road by poisons or the blood stasis of the road,which leads to the blood stasis and dysfunction of the micrangium(uterus),so the prescription and medication are mostly based on the three pathways and two pathways to restore the road function.For the road dysfunction,the sweet and mild qi-regulating pathway drugs and deficiency tonifying pathway drugs are used;For the blockage of the road by poison and evil,the spicy and warm or bitter and cold qi-regulating pathway drugs and detoxification pathway drugs are used;However,for the road blood stasis,the spicy and warm heat blood-stasis removing pathway drugs are used;The most frequently used drugs are Angeli-ca sinensis,Semen Cuscutae,Fructus Lycii,Fructus psoraleae,Radix Rehmanniae Praeparata and other 20 kinds of drugs.The core drug combination is Semen Cuscutae-Fructus Lycii.The commonly used drug combinations include Fructus Lycii→Semen Cuscutae,Morinda officinalis → Herba Epimedii-Semen Cuscutae,Fructus Lycii → Morinda officinalis-Herba Epimedii-Semen Cuscutae,etc.It is the main drug and drug combination of Huang's Zhuang medicine's empirical prescriptions,such as Huang's Zhuang medicine nourishing water channel nourishing Yin liquid decoction,Huang's Zhuang medicine warming and nourishing water channel to tonifying yang decoction,Huang's Zhuang medicine nourishing grain channel and strengthening spleen decoc-tion,Huang's Zhuang medicine qi-regulating and detoxification decoction,Huang's Zhuang medicine blood-stasis removing and regulating menstruation decoction,which can be used flexibly according to the dialectics,in order to provide guidance and refer-ence for the clinical medication and scientific research of Zhuang medicine for infertility treatment.

data miningNational Medicine MasterHuang Jinminginfertilitymedication rule

徐玉娟、王成龙、刘金伶、宋宁

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广西中医药大学,广西南宁 530200

广西中医药大学附属国际壮医医院,广西南宁 530001

数据挖掘 国医大师 黄瑾明 不孕症 用药规律

2024

西南民族大学学报(自然科学版)
西南民族大学

西南民族大学学报(自然科学版)

CSTPCD
影响因子:0.441
ISSN:2095-4271
年,卷(期):2024.50(6)