The mechanism of liver X receptor α and adenosine triphosphate binding cassette transporter A1 involved in the pathogenesis of preeclampsia
Objective To investigate the changes of LXRα and ABCA1 in preeclampsia and their relationship with abnormal lipid metabolism.Methods A total of 112 pregnant women who delivered in the Department of Obstetrics and Gynecology of Quanzhou First Hospital Affiliated to Fujian Medical University from October 2019 to June 2023 were selected(the preeclampsia group)and divided into early onset group,late onset group and normal control group according to whether they were diagnosed with preeclampsia before the 34th week of gestation;70 normal pregnant women hospitalized to give birth during the same period of time served as the normal control group(the normal group),and the levels of lipids in the serum were measured using biochemical methods(TG,TC,LDL and HDL);the expression of LXRα and ABCA1 protein levels in the serum of the 2 groups was detected by ELISA;and the expression of LXRα and ABCA1 in the placental tissues of the normal group and preeclampsia was detected by immunohistochemistry and semi-quantitative PCR(RT-PCR).The relationship between LXRα and ABCA1 expression and dyslipidemia was analyzed.Results TG,TC and LDL in preeclampsia group were higher than those in normal group,while HDL was lower,the difference was statistically significant(P<0.05).RT-PCR and immunohistochemistry showed that the expression of LXRα and ABCA1 in placenta and serum of preeclampsia group was lower than that of normal group,with statistical significance(P<0.05).There was a positive correlation between LXRα mRNA level and LXRα protein expression level in placenta,and the difference was statistically significant(P<0.05).The expression level of serum ABCA1 was positively correlated with the concentration of ABCA1 protein in the placenta,negatively correlated with the concentration of LDL in blood circulation,and positively correlated with the concentration of HDL in blood circulation,with significant statistical significance(P<0.05).Conclusion The level of blood lipids and the expression of LXRα and ABCA1 in serum of preeclampsia women are abnormal and correlated to the severity of the disease.LXRα and ABCA1 are involved in the occurrence of lipid metabolism abnormalities in preeclampsia,which can be used as a basis for clinically judging the progression of the associated course of the disease.
preeclampsialiver X receptor α(LXRα)triglyceridestotal cholesterolhigh density lipoproteinlow-density lipoprotein
万方数据
维普
