Response surface methodology for the preparation of bismuth potassium citrate intelligent spray hydrogel process
Objective To prepare a novel topical formulation for the treatment of complicated oral ulcers,the process parameters for the preparation of bismuth potassium citrate intelligent spray hydrogel were investigated.Methods The effects of the dosage of deacetylated gellan gum,glycerol,and poloxamer and the water bath temperature,and the volume ratio of gel matrix to isotonic solution on the intelligent spray hydrogel were investigated by one-way experiments using sprayability and viscosity as the composite scores,and the star-point design-effect surface optimization method test with the concentration of deacetylated gellan gum,and the volume ratios of poloxamer,and the gel matrix to the isotonic solution as the factors was established.Results The optimal process parameters for the preparation of bismuth potassium citrate intelligent spray hydrogel were analyzed by Design Expert 8.0.6.1 software and obtained as the mass fraction of gelling gel of 0.23%,the dosage of Poloxamer 188 1.03 g,and the mixed matrix is made from the volume ratio of gel matrix to isotonic soloution 13∶1.Conclusion The process produced a bismuth potassium citrate intelligent spray hydrogel with high comprehensive score,superior reproducibility and excellent operability,which is suitable for the industrial production of bismuth potassium citrate intelligent spray hydrogel.
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