海马在疼痛抑郁共病中的研究进展
Research Progress of Hippocampus in Pain and Depression Comorbidity
刘佳睿 1李岱 2朱海丽3
作者信息
- 1. 湖北科技学院医学部药学院,湖北 咸宁 437100
- 2. 湖北科技学院医学部口腔与眼视光医学院
- 3. 湖北科技学院医学部基础医学院
- 折叠
摘要
海马是大脑中的一个重要区域,对于记忆、情绪以及应激反应具有重要作用.疼痛和抑郁在临床上常常共同出现,且疼痛经常会加重抑郁症状,反之亦然.海马的结构和功能改变被认为是疼痛抑郁共病的重要神经生物学机制.本文深入回顾了海马在抑郁症、慢性疼痛以及疼痛抑郁共病状态下的形态结构变化与神经化学物质的调整,这些研究成果不仅为我们洞悉疼痛抑郁共病的病理生理机制提供了新的视角,也为探索和开发针对此类疾病的新型治疗策略奠定了坚实的理论基础与思路启发.
Abstract
The hippocampus is an important region of the brain that plays a role in memory,emotions and stress respon-ses.Pain and depression often co-occur clinically,and pain often worsens depressive symptoms,and vice versa.Structural and functional changes in the hippocampus are considered to be important neurobiological mechanisms of pain and depression comor-bidity.This paper reviews the relationship between morphological and neurochemical changes in the hippocampus with depression,chronic pain and pain depression comorbidities.These studies provide a new perspective for understanding the pathophysiological mechanisms of pain and depression comorbidity,and provide the possibility for developing new treatment strategies.
关键词
疼痛抑郁共病/海马神经可塑性变化/慢性疼痛/抑郁Key words
Pain and depression comorbidity/Neuroplasticity of hippocampus/Chronic pain/Depressed引用本文复制引用
出版年
2025
国家科技期刊平台
NSTL
万方数据