为研究氯胺酮滥用对长期依赖者认知功能的影响,在线检索了 PubMed、Cochrane Library、Web of Science英文数据库,中国知网和万方数据平台中文数据库,检索日期截至2022年1月.两名研究者各自独立提取文献信息,提取数据后应用Stata 14.0软件计算标准化均数差(standardized mean difference,SMD),95％可信区间(95％confidence interval,95％CI)以及异质性.结果显示,最终符合标准的研究有8项,其中观察组285例,健康对照组345例.Meta分析结果表明,与健康对照组相比,氯胺酮滥用损害依赖者的认知处理速度(SMD=-1.16,95％CI:-1.48～-0.83,z=7.05,P＜0.001)、言语记忆(SMD=-0.72,95％CI:-1.22～-0.22,z=-2.803,P=0.005)、视觉记忆(SMD=-0.70,95％CI:-1.18～-0.23,z=-2.890,P=0.004),且差异有统计学意义;而对于工作记忆(SMD=-0.05,95％CI:-0.66～0.55,z=0.18,P=0.859)和执行能力(SMD=0.19,95％CI:-0.27～0.66,z=0.81,P=0.418)的影响无统计学差异(P＞0.05).该结果说明,氯胺酮长期滥用可以显著损害依赖者的认知处理速度、言语记忆和视觉记忆,但未发现其对工作记忆与执行能力有显著作用.
Effects of Ketamine Abuse on Cognitive Function of Long-term Dependent Patients:A Meta-analysis
To investigate the effects of ketamine abuse on cognitive function in patients with long-term dependency,PubMed,Cochrane Library,Web of Science English database,CNKI,and Wanfang Data Platform Chinese databases were searched online until January 2022.Two researchers independently extracted literature information and then used the Stata software(version 14.0)to calculate the standardized mean difference(SMD),95％confidence interval(95％CI),and heterogeneity after data extraction.Eight studies met the inclusion criteria,with 285 patients in the observation group and 345 in the healthy control group.The results of the Meta-analysis showed that,compared with the healthy controls,ketamine abuse significantly impaired the cognitive processing speed(SMD=-1.16,95％CI:-1.48 to-0.83,z=7.05,P＜0.001),verbal memory(SMD=-0.72,95％CI:-1.22 to-0.22,z=-2.803,P=0.005),visual memory(SMD=-0.70,95％CI:-1.18 to-0.23,z=-2.890,P=0.004)in ketamine-dependent individuals.There were no significant differences in the working memory(SMD=-0.05,95％CI:-0.66 to 0.55,z=0.18,P=0.859)and executive ability(SMD=0.19,95％CI:-0.27 to 0.66,z=0.81,P=0.418)(P＞0.05).Long-term ketamine abuse can significantly impair the cognitive processing speed,verbal memory,and visual memory of dependent patients.However,no significant effect was observed on the working memory and executive ability.
万方数据
维普
