Qualitative Identification of a New Synthetic Opioid:Metonitazene
New synthetic opioids are on the growing list of illicit drugs and pose a serious threat to human health.Some examples of NSOs include AP 237,piperidine,bromomorphine and a variety of 2-benzyl benzimidazole opiates.2-benzyl benzimidazole opioids,also known as"Nitazenes",many of which are regulated by the United Nations Commission on Narcotic Drugs,have become internationally prevalent in recent years.Metonitazene is an emerging potent synthetic opioid that first appeared in the recreational drug supply in mid-2020 and began to surge by the end of the decade,raising increasing public health concerns.In this study,we presented a method for the identification of a novel synthetic opioid metonitazene seized for the first time in China by gas chromatography-mass spectrometry(GC-MS)and ultra-high performance liquid chromatography-quadrupole/electrostatic field Orbitrap-MS(UPLC-Q-Exactive Orbitrap-MS).The unknown samples were extracted by methanol,and the supernatants were analyzed by GC-MS and UPLC-Q-Exactive Orbitrap-MS respectively.Isotonitazene was analyzed as a contrast.By GC-MS detection,the main characteristic ion peaks of the mass spectral fragments of unknown component with retention time of 15.167 min were m/z 86.1(base peak),58.05,121.1,205.05,236.05 and 248.1.UPLC-Q-Exactive Orbitrap-MS detection showed that the excimer ion peak of unknown component with retention time of 7.35 min was m/z 383.207 7.The main ions of secondary mass spectrum were m/z 310.118 2,264.125 2,121.064 9,100.112 1 and 72.080 8.Due to the lack of reference substance,the target was identified as metonitazene by retrieval of SWGDRUG and Cayman database,comparison of information in reported literatures and analysis of high-resolution mass spectrometry data.The method is simple,rapid and has good application prospect.It can be used in real case detection.
novel synthetic opioidsmetonitazenegas chromatography and mass spectrometry(GC-MS)ultra high performance liquid chromatography-quadrupole/electrostatic field Orbitrap-MS(UPLC-Q-Exactive Orbitrap-MS)
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维普
