Research Progress of Non-coding RNA in Forensic Time-related Estimation
Forensic medicine is an applied discipline that uses medical and other related knowledge to provide scientific basis and evidence for criminal investigations,civil disputes,medical disputes,and other related fields involving law,to achieve justice and maintain social harmony and stability.Time-related estimations(TRE),such as estimations of time since death,wound age,and body fluid stain age,are important components of forensic identification,which can provide clues for case investigation,delineation of investigation scope,determination of crime time,and screening of alibis.Epigenetic has received much research in many fields and is highly valuable in forensic medicine because of its special mode of inheritance that is not based on changes of DNA sequences.Non-coding RNA(ncRNA)is currently regarded as an emerging epigenetic marker in a variety of fields,and the function and mechanism of ncRNAs in the physiological and pathological processes of different systems,organs,tissues,and cells revealed.Generally,ncRNAs may be divided into two groups based on their biological roles:housekeeping ncRNAs,which are critical for sustaining fundamental cellular activities,and regulatory ncRNAs,which act as regulators in cells.With the development of molecular biology,molecular genetics and bioinformatics,non-coding RNAs such as microRNA(miRNA)and circular RNA(circRNA)have shown great potentials for forensic identification,and they provide new methods for solving forensic problems of TRE.In this review,we summarized the common detection methods of ncRNAs in forensic medicine,and described the research progress and application of ncRNA such as miRNA and circRNA in estimation of time since death,wound age,and body fluid stain age,which show close links among them and forensic medicine.Additionally,we disscussed the research values and application prospects of non-coding RNA in the TRE.
non-coding RNAforensic medicinetime since deathwound agebody fluid stain ageepigenetic
万方数据
维普
