一起强奸致孕案中葡萄胎的亲子鉴定分析
Analysis of Paternity Testing for Hydatidiform Mole in a Rape Case
薛天羽 1林锦锋 1周镭迪欧 2秦金风 3倪春雨3
作者信息
- 1. 宁波市公安司法鉴定中心,浙江 宁波 315016
- 2. 宁海县公安司法鉴定中心,浙江 宁海 315600
- 3. 海尔施基因科技股份有限公司,浙江 宁波 315042
- 折叠
摘要
葡萄胎是异常受精所致的妊娠滋养细胞疾病.涉及葡萄胎组织的亲子鉴定在法医实践中相对罕见.在一起强奸致孕案中,受害人怀孕时未满14 周岁,经医院诊断为葡萄胎.流产组织的形态和基因分型特征符合完全性葡萄胎的特点,但被控嫌疑人和流产的葡萄胎组织不符合亲子关系.笔者结合相关文献对检验结果进行分析,通过DNA数据库单亲比对为追溯犯罪嫌疑人提供线索,并对本案相关人员样本和流产葡萄胎组织进行了多次复检,增加了X-STR和Y-STR基因座检验,进一步明确了流产葡萄胎组织的生物学父亲.本文对该案件的检验鉴定过程进行分析和探讨,以期为同类型案件的办理提供启示.
Abstract
Hydatidiform mole(HM)is a kind of gestational trophoblastic disease caused by abnormal fertilization.The presence of abundant paternal genetic information plays a key role in the pathogenesis of hydatidiform mole.Paternity testing involving hydatidiform mole tissue is relatively rare in forensic practice.In the case discussed,the aborted tissue originating from a female victim under 14 at the time of her pregnancy was diagnosed with hydatidiform mole.It was morphologically consistent with hydatidiform mole,and showed typical genotyping features of a complete hydatidiform mole(CHM)fertilized by single sperm,i.e.homozygous in all 23 loci.The alleged suspect was not actually the biological father of the aborted embryonic tissue.The author consulted a large number of literatures to analyze the experimental results.Unexplained paternity incompatibility suggests a different biological father,who was finally found through comparison and retrieval in the DNA database.Further STR testing was performed using VeriFilerTM Plus kit,SureID® X37 kit and YfilerTM.Platinum Casework kit.One allele was detected in 23 autosome and 35 X chromosome STR loci from embryonic tissue,which was found in the genotype of the focused suspect.The STR typing technology could determine the type of hydatidiform mole and provide clues and evidence for the identification.This paper may provide enlightenment for the handling of similar cases.
关键词
法医遗传学/DNA检验/亲子鉴定/葡萄胎Key words
forensic genetics/DNA examination/paternity testing/hydatidiform mole引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据