Analysis of Paternity Testing for Hydatidiform Mole in a Rape Case
Hydatidiform mole(HM)is a kind of gestational trophoblastic disease caused by abnormal fertilization.The presence of abundant paternal genetic information plays a key role in the pathogenesis of hydatidiform mole.Paternity testing involving hydatidiform mole tissue is relatively rare in forensic practice.In the case discussed,the aborted tissue originating from a female victim under 14 at the time of her pregnancy was diagnosed with hydatidiform mole.It was morphologically consistent with hydatidiform mole,and showed typical genotyping features of a complete hydatidiform mole(CHM)fertilized by single sperm,i.e.homozygous in all 23 loci.The alleged suspect was not actually the biological father of the aborted embryonic tissue.The author consulted a large number of literatures to analyze the experimental results.Unexplained paternity incompatibility suggests a different biological father,who was finally found through comparison and retrieval in the DNA database.Further STR testing was performed using VeriFilerTM Plus kit,SureID® X37 kit and YfilerTM.Platinum Casework kit.One allele was detected in 23 autosome and 35 X chromosome STR loci from embryonic tissue,which was found in the genotype of the focused suspect.The STR typing technology could determine the type of hydatidiform mole and provide clues and evidence for the identification.This paper may provide enlightenment for the handling of similar cases.
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