The structures of the effective components in the white crystals and colorless liquids,which were seized by Luzhou drug enforcement department,were analyzed by gas chromatography-mass spectrometry,liquid chromatography-quadrupole time-of-flight tandem mass spectrometer,nuclear magnetic resonance and Fourier transform infrared spectroscopy.Through sample analysis,it was found that the spectrograms of the two substances had no matching data with the existing database,and had a high degree of similarity.The accurate molecule mass of the two substances measured by liquid chromatography-quadrupole time-of-flight tandem mass spectrometer were the same,but the two substances have different retention times.In the next step,after analyzed by liquid chromatography-quadrupole time-of-flight tandem mass spectrometer and secondary mass spectrometry,it was found that in the secondary mass spectrum of white crystals,there were toluene fragments,and in the secondary mass spectrum of white liquids,there were phenyl fragments and ethylamine fragments,so it was inferred that the two substances were isomers.The proton attribution and carbon type of the two substances were analyzed by nuclear magnetic resonance and the carbonyl,amino and other functional groups were confirmed by infrared spectrum.The main component in white crystals was 2-(o-methylphenyl)-2-(methylamino)cyclohexanone,and the main component in colorless liquid was 2-(phenyl)-2-(ethylamino)cyclohexanone.The two substances are the new psychoactive substances of phenylcyclohexylpiperidine with the most active abuse currently,but the relevant data have not been reported in domestic literature,and there is a lack of relevant structural data reference.This paper comprehensively tested the structural data of the two substances,providing reference for combating new drug crimes and controlling the two substances.
new psychoactive substance(NPS)/2-(o-methylphenyl)-2-(methylamino)cyclohexanone/2-(phenyl)-2-(ethylamino)cyclohexanone/gas chromatography-mass spectrometry(GC-MS)/liquid chromatography-quadrupole time-of-flight tandem mass spectrometry(LC-QTOF/MS)/nuclear
维普
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