In order to reduce the cost of process quality control and improve the monitoring efficiency of control chart for different degrees of shifts,the optimization design of time-varying parameter adaptive cumu-lative sum(TVPACUSUM)chart is discussed in this paper.Firstly,an ACUSUM chart which can adjust the control chart parameters according to exponential weighted moving average(EWMA)shift estimators is pro-posed.Secondly,aiming at minimizing the average product length and average quality cost per unit product,a economic-statistical multi-objective optimization design model of the TVPACUSUM chart is constructed.Finally,in the case that the possible process shift is fixed or in a certain range,it is compared with control chart design methods in the existing literature.The results show that the time-varying parameter design can effectively improve the sensitivity of the control chart to the change of process state,and the optimization de-sign proposed in this paper can effectively improve the overall monitoring efficiency of ACUSUM chart while maintaining a low overall quality cost.