In the research of online agenda setting,there is insufficient emphasis on the network structure of mutual influence and agenda transmission among multiple users.This study attempts to emphasize the"gradient"agenda setting network structure from the perspective of inter subject agenda setting network.Through data mining and user segmentation,the network formed by transmitting and setting agendas between different layers is regarded as a relational matrix.Empirical testing found that the degree of agenda transmission between any two user layers is inversely proportional to the difference in the number of fans between these two layers,and directly proportional to the sum of the closeness centrality in the fan gap matrix between these two layers.The paper emphasizes the structural analysis of agenda setting network and extends the theory of agenda setting network,which helps to regulate the agenda setting path and optimal network in social networks.