Research progress on the role of mucin in the pathogenesis of gastroesophageal reflux disease
Gastroesophageal reflux disease(GERD)is a common recurrent disease and the treatment of GERD is challenging.Chronic heartburn and/or reflux symptoms seriously affect the quality of daily life of patients.Studies have shown that GERD is closely associated with the impairment of anti-reflux barrier of the esophagus,of which mucin(MUC)is the main component.The role of MUC in the pathogenesis of GERD and influencing factors were reviewed in this article.