Isthmin-1(ISM1)belongs to the Isthmin gene family.It is expressed in various tissues and has multiple biological functions.ISM1 is involved in growth and development,metabolism,immunity,tumorigenesis and other physiological and pathological processes,which is associated with a variety of lung diseases,including acute respiratory distress syndrome,chronic obstructive pulmonary disease and pulmonary fibrosis,etc.In this article,the structure,biological function of ISM1 and its role in pulmonary diseases were reviewed,aiming to provide a theoretical basis for the diagnosis and treatment of ISM1-related diseases.
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