Low triiodothyronine syndrome(LT3S)refers to the abnormal metabolism of thyroid hormones associated with critical illness,but without obvious symptoms of hypothyroidism.LT3S is closely associated with many critical diseases,such as severe burns,etc.During the occurrence and development of critical illness,many factors can induce LT3S by affecting the secretion,transfer and metabolism of thyroid hormones.LT3S is a risk factor for the development of critical illness and the occurrence of complications.It is a good indicator for evaluating the severity and prognosis of critical diseases.In this article,the pathogenesis,relationship with critical illness and treatment progress of LT3S were reviewed.
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