线粒体动力学相关蛋白与缺血性脑卒中研究进展
Research progress in mitochondrial dynamics-related proteins and ischemic stroke
李婷婷 1王钦鹏 2刘晓庆 1蔡珂 1魏阳阳 1梁成2
作者信息
- 1. 730030 兰州,兰州大学第二临床医学院
- 2. 730030 兰州,兰州大学第二医院神经内科ICU
- 折叠
摘要
缺血性脑卒中是临床常见的急危脑血管病,对人类健康构成了极大的威胁.近年来,随着对缺血性脑卒中的深入了解,其诊断和治疗取得了显著进展.然而缺血性脑卒中的病理机制极其复杂,目前的治疗手段也受到部分限制.研究显示,线粒体功能障碍在缺血性脑卒中的发病机制中起着重要的作用.通过线粒体动力学调控线粒体功能对于改善脑缺血神经细胞的损伤至关重要.文章就线粒体动力学的分子机制及对缺血性脑卒中的作用进行综述,以期为缺血性脑卒中的治疗提供有益的参考.
Abstract
Ischemic stroke is a common acute cerebrovascular disease in clinical practice,which poses a severe threat to human health.In recent years,with deepening understanding of ischemic stroke,significant progress has been made in the diagnosis and treatment.However,current treatments for ischemic stroke are partially limited due to extremely complex pathological mechanisms.Studies have shown that mitochondrial dysfunction plays an important role in the pathogenesis of ischemic stroke.Therefore,modulation of mitochondrial function through mitochondrial dynamics is essential to ameliorate the damage of cerebral ischemic neuronal cells.In this article,the molecular mechanism of mitochondrial dynamics and its role in ischemic stroke were reviewed,aiming to provide useful reference for the treatment of ischemic stroke.
关键词
缺血缺氧/线粒体动力学/氧化应激/炎症反应/细胞凋亡/坏死性凋亡/铁死亡Key words
Ischemia and hypoxia/Mitochondrial dynamics/Oxidative stress/Inflammatory reaction/Apoptosis/Necroptosis/Ferroptosis引用本文复制引用
基金项目
甘肃省科技厅自然科学研究项目(20210405JCC1549)
甘肃省神经病学重点实验室项目(20JR10RA766)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据