铁死亡抑制蛋白1在肿瘤中的作用
The role of ferroptosis suppressor protein 1 in tumors
李寒童 1李悦凡 1周妍 1王琳1
作者信息
- 1. 西安医学院口腔医学院,陕西 西安 710075
- 折叠
摘要
铁死亡抑制蛋白 1(FSP1)是铁死亡过程中的关键抑制因子,能够阻止细胞死亡,具有重要的生物学功能和潜在的临床应用价值.本研究详细探讨了FSP1 的发现背景、基因定位与结构特性,以及其在抑制铁死亡和促进细胞凋亡中的双重作用.临床研究已经开发出针对FSP1 的抑制剂,如铁死亡抑制蛋白 1 抑制剂(iFSP1)和相分离诱导型铁死亡抑制蛋白 1 抑制剂(icFSP1),未来的研究将进一步探讨FSP1 的表达调控机制、与肿瘤免疫逃逸的关联以及其作为肿瘤预后和治疗反应监测指标的潜力.
Abstract
Ferroptosis suppressor protein 1(FSP1)is a key suppressor in the process of ferroptosis,which can prevent cell death and has important biological functions and potential value in clinical application.In this article,the discovery background,gene localization and structural characteristics of FSP1,as well as its dual role in inhibiting ferroptosis and promoting apoptosis were explicitly discussed.In clinical researches,FSP1 inhibitors,such as iFSP1 and icFSP1,have been developed.Subsequently,the regulatory mechanisms of FSP1 expression,its association with tumor immune escape,and its potential as a monitoring indicator for tumor prognosis and therapeutic response will be investigated.
关键词
铁死亡/铁死亡抑制蛋白1/肿瘤/铁死亡抑制蛋白1抑制剂/相分离诱导型铁死亡抑制蛋白1抑制剂Key words
Ferroptosis/Ferroptosis suppressor protein 1/Tumor/iFSP1/icFSP1引用本文复制引用
基金项目
国家级大学生创新创业训练计划(2023)(202311840029)
出版年
2024
国家科技期刊平台
NSTL
万方数据