高密度脂蛋白与支气管哮喘关系研究进展
Research progress on the relationship between high density lipoprotein and bronchial asthma
毛文杰 1黄志英1
作者信息
- 1. 南京医科大学附属常州第二人民医院儿科,江苏 常州 213000
- 折叠
摘要
支气管哮喘(哮喘)是一种常见的肺部慢性炎症性疾病,会造成较大的健康问题和社会经济负担.近几十年来,我国哮喘患病率日益增高,多个因素协同作用影响哮喘的病情进展.越来越多的研究表明脂质代谢紊乱在哮喘发展过程中具有重要地位.高密度脂蛋白(HDL)具有胆固醇反向运输(RCT)、调节炎症和抗氧化等作用,还参与免疫系统的调节和脂质代谢.既往研究结果显示,血清HDL与哮喘的发生相关,重度哮喘和哮喘急性发作期患者血中HDL水平较低.该文综述了近年HDL与哮喘相关研究的进展,认为HDL参与了哮喘的免疫炎症过程,影响哮喘患者的肺功能,为临床相关研究提供了新的思路.
Abstract
Bronchial asthma is a common chronic inflammatory disease of the lung,which can cause great health problems and socioeconomic burden.In recent decades,the prevalence of asthma in China has been increasing,and multiple factors have synergistically affected the progress of asthma.More and more studies have found that lipid metabolism disorders play an important role in the development of asthma.High density lipoprotein(HDL)has the functions of reverse cholesterol transport(RCT),regulation of inflammation and anti-oxidation,and is also involved in the regulation of the immune system and lipid metabolism.Previous studies have shown that serum HDL is associated with the occurrence of asthma.The level of HDL in patients with severe asthma and acute exacerbation of asthma is low.
关键词
支气管哮喘/高密度脂蛋白(HDL)/载脂蛋白/脂质代谢Key words
Bronchial asthma/High density lipoprotein(HDL)/Apolipoprotein/Lipid metabolism引用本文复制引用
基金项目
常州市科技局应用基础研究项目(CJ20230067)
出版年
2024
国家科技期刊平台
NSTL
万方数据