Objective To evaluate the predictive value for serum albumin-globulin ratio(A/G)for the risk of Kawasaki disease(KD)in febrile children.Methods In this single-center retrospective cohort study,the big-data platform of a certain third-tier A-level hospital was employed.Clinical and laboratory data of 432 febrile children aged 0-16 were collected.The children were divided into 4 groups based on the quartiles and median of their serum A/G ratios.The correlation between the A/G and the risk of KD was analyzed.Results The total incidence rate of KD in 432 children with fever was 14.4%(62/432).A significant negative correlation was observed between the A/G and the risk of KD.For each increase of 0.1 in the A/G,the risk of KD was decreased by 18%(OR=0.82,95%CI 0.76-0.88,P<0.001).Subgroup analysis showed a consistent negative correlation between the A/G and KD risk across different ages,genders,and biochemical markers.Conclusions A/G may be a useful biomarker for assessing the risk of KD in febrile children.As the A/G increases,the risk of KD is gradually decreased.This finding has potential clinical application value for early diagnosis and risk assessment of KD.
维普
万方数据