Objective To evaluate the clinical application value of positional management guided by 12-zone lung ultrasound(LUS)in the treatment of neonatal infectious pneumonia.Methods A total of 76 neonates with a gestational age of>36 weeks and corrected gestational age of<44 weeks,clinically diagnosed with neonatal infectious pneumonia,were selected as the study subjects.They were randomly divided into the LUS-guided positional management group(treatment group)and conventional positional management group(control group).Compare the changes in LUS(assessed by LUS 12-zone score)before the intervention and on the 3rd and 7th days after the intervention,as well as the duration of oxygen therapy and hospital stay,between the two groups of children.Results Prior to intervention,the LUS scores in both groups were significantly higher than those of the anterior and lateral chest(all P<0.05).On 7th day after the intervention,the LUS scores of dorsal in the treatment group were significantly lower than those in the control group(P<0.05),and in both groups,the LUS scores of dorsal remained significantly higher than those of the anterior and lateral chest(all P<0.001).Additionally,the LUS scores of chest were significantly higher than those of the anterior chest(P<0.001).The total LUS score on 7th day after the intervention in the treatment group were significantly lower than that in the control group(P<0.05),and compared to pre-intervention and the 3rd day after the intervention,the total LUS score in the treatment group showed a significant decrease(both P<0.001).The length of hospital stay in the treatment group was significantly shorter than that in the control group(P<0.05).Conclusion Positional management guided by 12-zone LUS is beneficial in promoting the recovery from neonatal infectious pneumonia and shortening the length of hospital stay.