Objective To investigate the changes of angiotensin-converting enzyme(ACE)and angiotensin-converting enzyme 2(ACE2)levels in children with severe Mycoplasma pneumoniae pneumonia(SMPP)and evaluates their clinical values in predicting the severity of SMPP.Methods A total of 71 children with Mycoplasma pneumoniae pneumonia(MPP group)and 63 with severe Mycoplasma pneumoniae pneumonia(SMPP group)admitted to the Second Hospital of Lanzhou University from October 2020 to December 2023 were recruited in this study.Additionally,20 healthy children undergoing routine health check-ups during this period were selected as the control group.The serum concentrations of ACE and ACE2 in the three groups were measured using the enzyme-linked immunosorbent assay(ELISA),and laboratory test results were collected for comparison and correlation analysis between the MPP and SMPP groups.The receiver operating characteristic(ROC)curve was delineated to assess the predictive values of one single index or combined for SMPP.Results In the three groups,the serum ACE level was the highest in the SMPP group and the lowest in the healthy control group.The serum ACE2 level was the highest in the MPP group and the lowest in the healthy control group(all P<0.008).Compared to the MPP group,the SMPP group exhibited significantly elevated white blood cell count(WBC),neutrophil percentage(NE%),C-reactive protein(CRP),serum amyloid A protein(SAA),procalcitonin(PCT),interleukin-6(IL-6),erythrocyte sedimentation rate(ESR),and D-dimer(all P<0.001)and these indexes were positively correlated with ACE levels(all P<0.05),but negatively correlated with ACE2 levels(all P<0.05).The lymphocyte percentage(LY%)was significantly reduced(P<0.001),which was positively correlated with ACE2 levels(P<0.05),whereas negatively correlated with ACE levels(P<0.05).Lactate dehydrogenase(LDH)was elevated(P<0.05),which was negatively correlated with ACE2 levels(P<0.05),but not correlated with ACE levels(P>0.05).The monocyte percentage(MO%)showed neither significant difference nor correlation(both P>0.05).ROC curve analysis revealed that ACE,ACE2,CRP,D-dimer,LDH,and combined detection of ACE+ACE2,CRP+D-dimer+LDH all had predictive values for SMPP.Among them,the combined detection of ACE+ACE2 showed the highest predictive value,with an AUC of 0.991 and 95%CI:0.981-1.000.Conclusion The levels of ACE and ACE2 are likely associated with the onset and progression of SMPP in children,and both ACE and ACE2 serve as good indicators for predicting SMPP.
关键词
重症肺炎支原体肺炎/血管紧张素转换酶/血管紧张素转化酶2/肾素-血管紧张素系统/肺炎支原体肺炎
Key words
Severe Mycoplasma pneumoniae pneumonia/Angiotensin-converting enzyme/Angiotensin-converting enzyme 2/Renin-angiotensin system/Mycoplasma pneumoniae pneumonia
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