血清总IgE联合嗜酸性粒细胞对不同年龄阶段变应性鼻炎的诊断价值
Diagnostic value of total serum IgE levels combined with eosinophils in allergic rhinitis at different ages
谷悦 1沈暘 1熊攀辉 1官大宇 1卢韬 1杨玉成1
作者信息
- 1. 重庆医科大学附属第一医院耳鼻咽喉科,重庆 400016
- 折叠
摘要
目的 探讨血清总免疫球蛋白E(IgE)、嗜酸性粒细胞(EOS)及其百分比在不同年龄阶段的变应性鼻炎(AR)诊断价值,并构建血清总IgE联合EOS初步诊断AR的诊断模型.方法 回顾性分析 2023 年 4 月至 2024 年4 月就诊于重庆医科大学附属第一医院耳鼻咽喉科 305 例AR患者、256 例非AR患者的临床资料,比较 2 组患者一般资料、血清总IgE水平、EOS计数及其百分比之间的差异,用二元Logistic回归分析筛选合适指标构建诊断模型,并绘制受试者操作特征(ROC)曲线,以曲线下面积(AUC)来判断模型的诊断价值.收集 2019 年 6 月至 2022 年 6 月就诊于重庆医科大学附属第一医院耳鼻咽喉科AR及非AR患者共 216 例资料,进行外部验证.根据年龄分组[青少年组(≤18 岁)、青年组(19～45 岁)、中年组(46～60 岁)、老年组(>60 岁)]进行分层分析.结果 总体以及各年龄组均显示EOS百分比及总IgE为AR的影响因素,所有患者联合诊断模型:Logit P=-4.174+6.856EOS计数+0.048总IgE;青少年组诊断模型:Logit P=-4.472+0.637EOS百分比+0.034 总IgE;青年组诊断模型:Logit P=-4.491+0.372EOS百分比+0.068 总IgE;中年组诊断模型:Logit P=-4.759+5.768EOS计数+0.062 总IgE;老年组诊断模型:Logit P=-4.888+0.855EOS百分比+0.028 总IgE.Hosmer-Lemeshow拟合优度检验、ROC曲线分析、外部验证均显示了上述模型具有较高的诊断价值.结论 血清总IgE水平联合EOS对不同年龄段AR具有良好诊断价值,可用于指导AR初步诊断.
Abstract
Objective To evaluate the diagnostic value of total serum immunoglobulin E(IgE)levels,eosinophil(EOS)count and percentage in the diagnosis of allergic rhinitis(AR),and to construct a diagnostic model for preliminary diagnosis of AR by combining total serum IgE and EOS.Methods Clinical data of 305 AR patients and 256 non-AR patients admitted to Department of Otolaryngology at the First Affiliated Hospital of Chongqing Medical University from April 2023 to April 2024 were retrospectively analyzed.The general information,total serum IgE level,EOS count and percentage were compared between two groups.Binary logistic regression analysis was used to screen for suitable indicators to construct the predictive model,and the receiver operating characteristic(ROC)curve was plotted.The area under the ROC curve(AUC)was used to determine the predictive value of this model.Clinical data from 216 patients with and without AR admitted to Department of Otolaryngology at the First Affiliated Hospital of Chongqing Medical University from June 2019 to June 2022 were collected for external validation.Stratification analysis was performed according to age[adolescent group(≤18 years old),youth group(19-45 years old),middle-aged group(46-60 years old),and elderly group(>60 years old)],respectively.Results The percentage of EOS and total serum IgE level were the influencing factors of AR in the overall and all age groups.The combined diagnostic model for all patients was:Logit P=-4.174+6.856EOS count+0.048total serum IgE.Diagnostic model in adolescent group was:Logit P=-4.472+0.637EOS percentage+0.034total serum IgE;youth group:Logit P=-4.491+0.372EOS percentage+0.068total serum IgE;middle-aged group:Logit P=-4.759+5.768EOS count+0.062total serum IgE;elderly group:Logit P=-4.888+0.855EOS percentage+0.028total serum IgE,respectively.Hosmer-Lemeshow goodness-of-fit test,ROC curve analysis and external validation all indicated that this model had high diagnostic value.Conclusion The combination of total serum IgE levels and EOS count demonstrates good diagnostic value for AR in different age groups,which can be used to guide preliminary diagnosis of AR.
关键词
变应性鼻炎/免疫球蛋白E/嗜酸性粒细胞/诊断价值Key words
Allergic rhinitis/Immunoglobulin E/Eosinophil/Diagnostic value引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据