Observation on the efficacy of Rhinitis Formula No.1 combined with Seretide on the treatment of allergic rhinitis complicated with asthma
Objective To explore the effect of Rhinitis Formula No.1 combined with Seretide on the treatment of allergic rhinitis complicated with asthma,aiming to provide a new clinical basis for the application of Lingnan Traditional Chinese Medicine in the integrated treatment of nasal and lung diseases.Methods One hundred and forty patients who met the combined diagnosis of allergic rhinitis and asthma were randomly divided into the Western Medicine group and the Traditional Chinese medicine(TCM)combined with Western Medicine group,with 70 cases in each group.The Western Medicine group received routine treatment with Seretide.The TCM and Western Medicine group,in addition to Seretide,was administered Rhinitis Formula No.1(consisting of 15 g Codonopsis pilosula,6 g Glycyrrhiza uralensis Fisch,10 g Terminalia chebula Retz,10 g Platycodon grandiflorus,3 g Asarum sieboldii,10 g Schizonepeta tenuifolia,15 g Radix Rehmanniae Praeparata,10 g Poria cocos,3 g Ramulus Cinnamomi,6 g dried tangerine peel,6 g Morinda officinalis,and 10 g smoked plum)once daily,divided into two doses.Both groups were continuously observed for two weeks.The two groups were compared based on the self-developed TCM Symptom Scale Score,Total Nasal Symptom Score(TNSS),Total Nasal and Non-Nasal Symptom Score(TNNSS),Asthma Control Test Scores(ACT),indicators of immune function and inflammation,and adverse reactions before and after treatment.Results In the Western Medicine group,7 patients dropped out,and in the TCM combined with Western Medicine group,5 patients dropped out.The patients who dropped out were included in the safety analysis but were not included in the statistical analysis of efficacy.The general data of the two groups was comparable,and there were no significant differences in the TCM Symptom Scale Scores,TNSS,TNNSS and ACT before treatment between the two groups(all P>0.05).After treatment,the TCM Symptom Scale Scores(P<0.001),TNSS(P<0.001),and TNNSS(P=0.001)in the TCM combined with Western Medicine group were lower than those in the Western Medicine group,while the ACT in the TCM combined with Western Medicine group was higher than those in the Western Medicine group(all P<0.05).The improvements in TCM Symptom Scale Scores,TNSS,TNNSS,and ACT in the TCM combined with Western Medicine group were superior to those in the Western Medicine group(all P<0.05).After treatment,the levels of IgA and IgG in both groups were higher than pretherapy,while the level of IgE was lower than pretherapy;the levels of IgA and IgG in the TCM combined with Western Medicine group were higher than those in the Western Medicine group,and the level of IgE was lower than that in the Western Medicine group(all P<0.05).After treatment,the levels of IL-10 in both groups were higher than pretherapy,and the levels of IL-6 and IL-17 were lower than pretherapy;the level of IL-10 in the TCM combined with Western Medicine group was higher than that in the Western Medicine group,and the levels of IL-6 and IL-17 were lower than those in the Western Medicine group(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions between two groups(P=0.753).Conclusions Compared to the use of seretide alone,the combination of Rhinitis Formula No.1 with Seretide demonstrates superior efficacy in the treatment of allergic rhinitis complicated with asthma.
Allergic rhinitisAsthmaIntegrated Traditional Chinese and Western MedicineLingnan Traditional Chinese Medicinal PrescriptionRhinitis Formula No.1
万方数据
维普
