Expression of plasma malondialdehyde and glutathione peroxidase in patients with atrial fibrillation
Objective To analyze the levels of plasma oxidative stress biomarkers in atrial fibrillation ( AF) and their relationship with atrial structural remodeling.Methods A total of 43 patients with valvular heart disease in the Af-filiated hospital of Xuzhou Medical University were divided into two groups: a continuous AF group ( Group AF, where the fibrillation lasted more than 7 days, n=21) and a sinus rhythm group (Group SR, n=22).The peripheral venous blood samples were collected before surgery to determine the amounts of malondialdehyde ( MDA) and glutathione peroxi-dase ( GSH-Px) .Ultrasonic cardiogram reports were collected before surgery to analyze the left atrial diameter ( LAD) . Results The LAD was (56.90 ±9.93) mm for Group AF, which was significantly larger than that in Group SR (40.59 ±9.40) mm (P<0.01).The content of MDA was (8.07 ±0.32) nmol/mg in Group AF, which was significantly lar-ger than that in Group SR (4.23 ±0.23) nmol/mg (P<0.05).The content of GSH-Px was (127.26 ±12.12) U in Group AF, which was remarkably lower than that in Group SR (168.91 ±18.25) U (P<0.05).MDA was markedly related with LAD in AF patients (P<0.05).Conclusions Oxidative stress is significantly enhanced in AF patients with valvular heart disease.Oxidative stress is likely to be involved in structural remodeling and atrial fibrillation.
NETL
NSTL
万方数据
维普
